(CBS News) A newborn rat pup in the lab of Dr. Marc Breedlove at Michigan State University, may, oddly enough, hold important clues to what happens in the womb.
Dr. Breedlove says he can take a male rat and make it behave like a female for the rest of its life, and vice versa for a female, just by altering the hormones it's exposed to at birth. Because rats are born underdeveloped, that's roughly the same as altering a third-trimester human fetus in the womb. But first, he said, Stahl would need a crash course in rat sex.
Dr. Breedlove explained that male rats, including one he showed Stahl called "Romeo," will mount any rat that comes their way. In the mating process, the female performs something called lordosis, where she lifts her head and rump.
If Romeo goes after a male, Dr. Breedlove says the male will seem profoundly indifferent.
But Breedlove says he can change all that. He gave a female rat a single shot of the male sex hormone testosterone at birth. Now grown up, she will never perform lordosis.
But a male rat did. He was castrated at birth, depriving him of testosterone.
"So you created a gay rat?" Stahl asked.
"I wouldn't say that these are gay rats. But I will say that these are genetic male rats who are showing much more feminine behavior," he explained.
So the answer may be that it's not genes but hormones.
"That's exactly the question that we're all wondering. This business of testosterone having such a profound influence. Does that have some relevance to humans?" Breedlove said.
While biologists look at hormones for answers about human sexuality, other scientists are looking for patterns in statistics. And hard as this is to believe, they have found something they call "the older brother effect."
"The more older brothers a man has, the greater that man's chance of being gay," says Bailey.
Asked if that's true, Bailey says, "That is absolutely true."
If this comes as a shock to you, you’re not alone. But it turns out, it’s one of the most solid findings in this field, demonstrated in study after study.
And the numbers are significant: for every older brother a man has, his chances of being gay increase by one third. Older sisters make no difference, and there's no corresponding effect for lesbians. A first-born son has about a 2 percent chance of being gay, and the numbers rise from there. The theory is it happens in the womb.
"Somehow, the mother's body is remembering how many boys she's carried before," says Breedlove. "The favorite hypothesis is that the mother may be making antibodies when she sees a boy the first time, and then affect subsequent boys when she carries them in utero."
"You mean, like she's carrying a foreign substance?" Stahl asked.
"And if you think about it, a woman who's carrying a son for the first time, she is carrying a foreign substance," Breedlove replied. "There are some proteins encoded on his Y chromosome that her body has never seen before and that her immune system would be expected to regard as 'invaders,'" he added.
It’s still not a proven theory and it gets even stranger.
"One of the things we've only found out lately is that older brothers affect a boy only if the boy is right-handed," Breedlove said. "If the boy is left-handed, if his brain is organized in a left-handed fashion, it doesn't matter how many older brothers he has, his probability of being gay is just like the rest of the population."
You can give yourself a headache trying to apply all the theories to real people. Greg and Steve Lofts both are right-handed, and they do have an older brother, so maybe that's why Greg is gay. But they also have several gay relatives, which suggests it could be in the genes, except where does that leave Steve?
Adam and Jared, fraternal twins, have older brothers, but they're ambidextrous.
Then there's the question of how something in the womb could affect one twin but not the other. There are many more questions at this point than answers, but the scientists 60 Minutes spoke to are increasingly convinced that genes, hormones, or both — that something is happening to determine sexual orientation before birth. Adam has come up with his own theory.
"I was supposed to be a girl in my mom's stomach. But my mom wished for all boys. So, I turned into a boy," Adam explained.
Asked if he wished he was a girl, Adam nodded.
"Do you think there was anything that you could have done that would have changed Adam?" Stahl asked Adam and Jared's mom Danielle.
"I could have changed Adam on the outside to where he would have showed me the macho boy that I would want as a boy. But that would not change who he is inside. And I think that would have damaged him a lot more," she said.
Stahl asked both boys if they are proud of the way they are, and both boys gave her big nods.
"Yup," Adam replied.
